{"title":"非糖尿病、非胰岛素依赖型糖尿病和胰岛素依赖型糖尿病患者的坐骨神经磷脂谱。31P核磁共振波谱研究","authors":"David Driscoll , William Ennis , Patricio Meneses","doi":"10.1016/0020-711X(94)90105-8","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Human sciatic nerve phospholipids obtained from non-diabetes mellitus (NDM), non-insulin-dependent diabetes mellitus (NIDDM), and insulin-dependent diabetes mellitus (IDDM) patients, after lower extremity amputation, were studied by <sup>31</sup>P NMR spectrometry.</p></span></li><li><span>2.</span><span><p>2. Nine phospholipids resonances in NDM and NIDDM groups were identified as followed: Ethanolamine plasmalogen (Epias, Chemical shift = 0.07δ); phosphatidylethanolamine (PE, 0.03δ); phosphatidylserine (PS, −0.05δ); sphingomyelin (SM, −0.09δ); lysophosphatidylcholine (LPC, −0.28δ); phosphatidylinositol (PI, −0.30δ); alkylacylphosphorylcholine (A1.PC, -0.78δ); phosphatidylcholine (PC −0.84δ), and an unknown resonance (U, 0.13δ).</p></span></li><li><span>3.</span><span><p>3. In the IDDM group a resonance of lysophosphatidylinositol (LPI, 0.01δ) was detected in addition to the nine phospholipids listed above.</p></span></li><li><span>4.</span><span><p>4. IDDM showed that PI and Al.PC were elevated and U was lower when compared with NDM; also, Eplas was lower when compared with NIDDM. PC was elevated and PS was lower when compared with both NDM and NIDDM.</p></span></li><li><span>5.</span><span><p>5. Indices calculated from this data, showed that the choline ratio and choline/ ethanolamine ratio were elevated; while ethanolamine ratio, and myelin ratio were lower in IDDM group, when compared with both NDM and NIDDM groups.</p></span></li><li><span>6.</span><span><p>6. Inactivation of the cholineacethyltransferase enzyme (ChAT) and enhancement of the phospholipidmethyltransferase enzyme (PLMT), secondary to an insulin deficiency, are proposed as an interpretation of these findings.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 6","pages":"Pages 759-767"},"PeriodicalIF":0.0000,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90105-8","citationCount":"12","resultStr":"{\"title\":\"Human sciatic nerve phospholipid profiles from non-diabetes mellitus, non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus individuals. A 31P NMR spectroscopy study\",\"authors\":\"David Driscoll , William Ennis , Patricio Meneses\",\"doi\":\"10.1016/0020-711X(94)90105-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Human sciatic nerve phospholipids obtained from non-diabetes mellitus (NDM), non-insulin-dependent diabetes mellitus (NIDDM), and insulin-dependent diabetes mellitus (IDDM) patients, after lower extremity amputation, were studied by <sup>31</sup>P NMR spectrometry.</p></span></li><li><span>2.</span><span><p>2. Nine phospholipids resonances in NDM and NIDDM groups were identified as followed: Ethanolamine plasmalogen (Epias, Chemical shift = 0.07δ); phosphatidylethanolamine (PE, 0.03δ); phosphatidylserine (PS, −0.05δ); sphingomyelin (SM, −0.09δ); lysophosphatidylcholine (LPC, −0.28δ); phosphatidylinositol (PI, −0.30δ); alkylacylphosphorylcholine (A1.PC, -0.78δ); phosphatidylcholine (PC −0.84δ), and an unknown resonance (U, 0.13δ).</p></span></li><li><span>3.</span><span><p>3. In the IDDM group a resonance of lysophosphatidylinositol (LPI, 0.01δ) was detected in addition to the nine phospholipids listed above.</p></span></li><li><span>4.</span><span><p>4. IDDM showed that PI and Al.PC were elevated and U was lower when compared with NDM; also, Eplas was lower when compared with NIDDM. PC was elevated and PS was lower when compared with both NDM and NIDDM.</p></span></li><li><span>5.</span><span><p>5. Indices calculated from this data, showed that the choline ratio and choline/ ethanolamine ratio were elevated; while ethanolamine ratio, and myelin ratio were lower in IDDM group, when compared with both NDM and NIDDM groups.</p></span></li><li><span>6.</span><span><p>6. Inactivation of the cholineacethyltransferase enzyme (ChAT) and enhancement of the phospholipidmethyltransferase enzyme (PLMT), secondary to an insulin deficiency, are proposed as an interpretation of these findings.</p></span></li></ul></div>\",\"PeriodicalId\":13733,\"journal\":{\"name\":\"International Journal of Biochemistry\",\"volume\":\"26 6\",\"pages\":\"Pages 759-767\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-711X(94)90105-8\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0020711X94901058\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020711X94901058","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Human sciatic nerve phospholipid profiles from non-diabetes mellitus, non-insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus individuals. A 31P NMR spectroscopy study
1.
1. Human sciatic nerve phospholipids obtained from non-diabetes mellitus (NDM), non-insulin-dependent diabetes mellitus (NIDDM), and insulin-dependent diabetes mellitus (IDDM) patients, after lower extremity amputation, were studied by 31P NMR spectrometry.
2.
2. Nine phospholipids resonances in NDM and NIDDM groups were identified as followed: Ethanolamine plasmalogen (Epias, Chemical shift = 0.07δ); phosphatidylethanolamine (PE, 0.03δ); phosphatidylserine (PS, −0.05δ); sphingomyelin (SM, −0.09δ); lysophosphatidylcholine (LPC, −0.28δ); phosphatidylinositol (PI, −0.30δ); alkylacylphosphorylcholine (A1.PC, -0.78δ); phosphatidylcholine (PC −0.84δ), and an unknown resonance (U, 0.13δ).
3.
3. In the IDDM group a resonance of lysophosphatidylinositol (LPI, 0.01δ) was detected in addition to the nine phospholipids listed above.
4.
4. IDDM showed that PI and Al.PC were elevated and U was lower when compared with NDM; also, Eplas was lower when compared with NIDDM. PC was elevated and PS was lower when compared with both NDM and NIDDM.
5.
5. Indices calculated from this data, showed that the choline ratio and choline/ ethanolamine ratio were elevated; while ethanolamine ratio, and myelin ratio were lower in IDDM group, when compared with both NDM and NIDDM groups.
6.
6. Inactivation of the cholineacethyltransferase enzyme (ChAT) and enhancement of the phospholipidmethyltransferase enzyme (PLMT), secondary to an insulin deficiency, are proposed as an interpretation of these findings.
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