Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.
{"title":"二十碳五烯酸提高培养的人内皮细胞胞内游离钙","authors":"Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.","doi":"10.1006/bmmb.1994.1021","DOIUrl":null,"url":null,"abstract":"<div><p>Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca<sup>2+</sup>]<sub>i</sub> could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca<sup>2+</sup> mobilization, causing the elevation of [Ca<sup>2+</sup>]<sub>i</sub>.</p></div>","PeriodicalId":8752,"journal":{"name":"Biochemical medicine and metabolic biology","volume":"51 2","pages":"Pages 166-168"},"PeriodicalIF":0.0000,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/bmmb.1994.1021","citationCount":"12","resultStr":"{\"title\":\"Eicosapentaenoic Acid Enhances Intracellular Free Calcium in Cultured Human EndothelialCells\",\"authors\":\"Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.\",\"doi\":\"10.1006/bmmb.1994.1021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca<sup>2+</sup>]<sub>i</sub> could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca<sup>2+</sup> mobilization, causing the elevation of [Ca<sup>2+</sup>]<sub>i</sub>.</p></div>\",\"PeriodicalId\":8752,\"journal\":{\"name\":\"Biochemical medicine and metabolic biology\",\"volume\":\"51 2\",\"pages\":\"Pages 166-168\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/bmmb.1994.1021\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemical medicine and metabolic biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0885450584710218\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemical medicine and metabolic biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0885450584710218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Eicosapentaenoic Acid Enhances Intracellular Free Calcium in Cultured Human EndothelialCells
Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca2+]i could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.
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