化疗剂量强度对Wilms肿瘤血液学毒性的影响。一份来自国家肿瘤研究的报告。

D M Green, N E Breslow, I Evans, J Moksness, J Z Finklestein, A E Evans, G J D'Angio
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引用次数: 38

摘要

目的:确定在国家Wilms肿瘤研究的前28个月随机接受治疗的患者的血液学毒性与实际治疗剂量强度之间的关系-4。方法:比较1986年8月6日至1988年12月31日参加美国国家肿瘤研究4 (National Wilms' Tumor研究4)的所有随机患者在化疗前两个疗程的平均最低白细胞计数(WBC)、血小板计数(PLT)、血红蛋白和绝对中性粒细胞计数(ANC)以及因毒性而住院的平均天数。比较标准方案和“脉冲强化”方案在前两个疗程和整个疗程中接受的放线菌素、长春新碱和阿霉素的平均剂量强度。结果:与“脉冲强化”方案相比,在标准方案治疗的I期患者的前两个化疗疗程中,平均最小WBC、PLT和ANC均显着降低。与适当的标准方案相比,接受“脉冲强化”方案治疗的患者,放线菌素和阿霉素的平均剂量强度明显更高。结论:治疗儿童Wilms肿瘤的“脉冲强化”给药方案允许以更高的剂量强度施用化疗,而不会增加血液毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of chemotherapy dose intensity on the hematological toxicity of the treatment for Wilms' tumor. A report from the National Wilms' Tumor Study.

Purpose: To determine the relationship between hematological toxicity and actual dose intensity of treatment of patients randomized to therapy during the first 28 months of the National Wilms' Tumor Study-4.

Methods: The mean minimum white blood cell count (WBC), platelet count (PLT), hemoglobin, and absolute neutrophil count (ANC) during the first two courses of chemotherapy and the mean number of days of hospitalization for toxicity were compared between standard and "pulse-intensive" regimens for all randomized patients entered on National Wilms' Tumor Study-4 between August 6, 1986 and December 31, 1988. The mean dose intensity of dactinomycin, vincristine, and doxorubicin received during the first two courses and the entire course of treatment was compared between standard and "pulse-intensive" regimens.

Results: The mean minimum WBC, PLT, and ANC were all significantly lower during the first two courses of chemotherapy for stage I patients treated with the standard regimen, compared with the "pulse-intensive" regimen. The mean dose intensity of dactinomycin and doxorubicin was significantly higher for patients treated with the "pulse-intensive" regimens, compared with the appropriate standard regimen.

Conclusions: The "pulse-intensive" administration schedule for the treatment of children with Wilms' tumor permits administration of chemotherapy at a higher dose intensity without an increase in hematological toxicity.

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