{"title":"皮质丘脑神经元网络的睡眠振荡及其发展为自我持续的发作性活动。","authors":"M Steriade","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.</p>","PeriodicalId":77370,"journal":{"name":"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sleep oscillations in corticothalamic neuronal networks and their development into self-sustained paroxysmal activity.\",\"authors\":\"M Steriade\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.</p>\",\"PeriodicalId\":77370,\"journal\":{\"name\":\"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sleep oscillations in corticothalamic neuronal networks and their development into self-sustained paroxysmal activity.
Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.