嘌呤霉素氨基核苷注射大鼠组织脂质过氧化和谷胱甘肽过氧化物酶活性

International Journal of Biochemistry Pub Date : 1994-09-01 DOI:10.1016/0020-711X(94)90136-8

José Pedraza-Chaverrí, Ana Elena Arévalo

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引用次数: 7

摘要

1.1. 2.2分别在给药或给药后第1-6、8、10、16和22天，测定对照组和注射嘌呤霉素氨基核苷大鼠肾脏、肝脏、心脏、肺、脑和睾丸的脂质过氧化物酶(LPx)和谷胱甘肽过氧化物酶(GPx)活性。注射pan的大鼠在第3.3.3天出现蛋白尿。pan注射大鼠:(a)第3天前肾、肝、肺、脑和睾丸中LPx升高，第3天心脏中LPx升高;(b) GPx活性在第3天或之后在肾、肝、心、肺和睾丸中升高，在脑中降低。

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Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats

1.
1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1–6, 8, 10, 16 and 22 after vehicle or PAN injection.
2.
2. PAN-injected rats developed proteinuria on day 3.
3.
3. In PAN-injected rats: (a) LPx increased in kidney, liver, lung, brain and testis before day 3 and in heart on day 3; (b) GPx activity increased in kidney, liver, heart, lung and testis and diminished in brain on day 3 or after.

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来源期刊

International Journal of Biochemistry

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