Sphenoid sinus involvement in neuroblastoma.

Purpose: Malignancy of the sphenoid sinus, especially metastatic involvement, is an extremely rare event at any age and is usually associated with a poor prognosis. We present a case of a 5-year-old boy who underwent allogenic bone marrow transplantation for stage IV neuroblastoma.

Patients and methods: Three years later, he presented with an isolated lesion, histologically proven to be neuroblastoma, in the sphenoid sinus.

Results: Partial excision of the tumor, followed by chemotherapy and radiotherapy, achieved a remission for 3 years.