Y Suzuki, M Nanno, R Gemma, I Tanaka, T Taminato, T Yoshimi
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引用次数: 67
摘要
为了阐明糖尿病患者甲状腺激素水平受损的机制，研究人员检测了甲状腺激素、甲状腺激素结合抑制剂（THBI）、甲状腺外T4转化为T3的抑制剂（IEC）和游离脂肪酸（FFA）。此外，还对血糖控制前后血糖控制不佳的 9 名糖尿病患者进行了 TRH 测试。血糖控制前，空腹血浆葡萄糖和 HbA1c 明显高于血糖控制后（P < 0.05）。血糖控制后，T3 和 T3/T4 比值明显升高，rT3 明显降低（P < 0.05）。血糖控制后，THBI指数和血浆FFA水平明显下降，T3产生率（IEC）明显上升（P < 0.05）。血糖控制后，TSH 对 TRH 的反应明显增加。总之，(1)THBI的存在，(2)IEC的存在，以及(3)下丘脑-下丘脑-甲状腺轴的功能障碍被认为是糖尿病患者甲状腺功能异常的原因。
[The mechanism of thyroid hormone abnormalities in patients with diabetes mellitus].
In order to clarify the mechanism of impaired thyroid hormone levels in patients with diabetes mellitus, thyroid hormone, thyroid hormone binding inhibitor (THBI), inhibitor of extrathyroidal conversion of T4 to T3 (IEC) and free fatty acid (FFA) were examined. In addition, TRH test was performed on 9 diabetic patients showing poor control of plasma glucose before and after glycemic control. Before glycemic control, fasting plasma glucose and HbA1c were significantly higher than after glycemic control (P < 0.05). T3 and the T3/T4 ratio significantly increased and rT3 significantly decreased after glycemic control (P < 0.05). THBI index and plasma FFA level significantly decreased and %T3 production (IEC) significantly increased after glycemic control (P < 0.05). The response of TSH to TRH significantly increased after glycemic control. In conclusion, (1) the presence of THBI, (2) the presence of IEC, and (3) dysfunction of the hypothalamo-hypophysial-thyroid axis are considered to be involved in abnormal thyroid function in diabetic patients.
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