尼莫地平对新生仔猪脑及器官血流的影响。

J P Odden, E B Roll, C Hall, D Bratlid
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引用次数: 3

摘要

采用同位素标记微球法研究了新生仔猪尼莫地平输注过程中脑、心、肾血流量的变化。20头仔猪分为两组。组1 (n = 8)保持常氧,给予尼莫地平持续输注(15微克/kg/min)。第2组(n = 12)通过呼吸10% O2 10分钟,然后与第1组相同的尼莫地平输注使低氧血症。尽管出现了明显的全体性低血压,但单独输注尼莫地平在输注30-60 min时脑干和右心室的血流量明显增加,而小脑、大脑和左心室的血流量没有变化。肾脏的血流量明显减少。尼莫地平输注后乙肝毒仔猪的血流模式几乎相似,但这种变化出现的时间较早。我们得出结论,尽管血压显著降低,但即使在高剂量的尼莫地平下,正常动物和血毒后动物的脑和心脏血流仍保持不变。然而,由于流向肾脏的血流量减少,在临床应用于窒息新生儿之前,需要进一步的剂量反应研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of nimodipine on cerebral and organ blood flow in normal and posthypoxemic newborn piglets.

Using the isotope-labelled microsphere method, blood flow to the brain, the heart and the kidneys were studied in newborn piglets during nimodipine infusion. Twenty piglets were studied in two different groups. Group 1 (n = 8) was kept normoxic and given a continuous nimodipine infusion (15 micrograms/kg/min). Group 2 (n = 12) was made hypoxemic by breathing 10% O2 for 10 min followed by an identical nimodipine infusion as group 1. In spite of a significant systemic hypotension, nimodipine infusion alone significantly increased blood flow in the brain stem and right cardiac ventricle at 30-60 min of infusion, while blood flow to cerebellum, cerebrum and the left cardiac ventricle did not change. Blood flow to the kidneys decreased significantly. In posthypoxemic piglets nimodipine infusion gave almost similar flow patterns, however, the changes appeared at an earlier time. We conclude that in spite of a significant reduction in blood pressure, cerebral and cardiac blood flow is preserved both in normal and posthypoxemic animals even at high doses of nimodipine. However, because of the decreased blood flow to the kidneys further dose-response studies are needed before clinical use in asphyctic newborns.

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