CVI的淋巴细胞亚群异常与IL-6的产生增加无关。

Immunodeficiency Pub Date : 1993-01-01

F Pandolfi, R Paganelli, A Cafaro, A Oliva, A Giovannetti, E Scala, I Quinti, F Aiuti

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摘要

我们测定了49例普通可变免疫缺陷(CVI)患者淋巴细胞亚群的百分比和绝对数量。还评估了28例患者的pha刺激PBMC体外产生IL-6的情况。我们的数据表明，淋巴细胞亚群发生了深刻的变化，包括CD8细胞增加(26例中这些细胞数量超过CD4细胞)，10例中CD4细胞严重缺陷(< 400/mm3)， 11/41例中CD19细胞减少(< 50/mm3)。CVI患者PBMC体外产生IL-6的增加与淋巴细胞、淋巴细胞亚群或单核细胞的绝对数量无关。此外，IL-6不能显著改变CVI细胞中pwm驱动的IgM产生量。

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Abnormalities of lymphocyte subpopulations in CVI do not correlate with increased production of IL-6.

We have determined the percentages and absolute numbers of lymphocyte subpopulations in 49 patients with common variable immunodeficiency (CVI). In vitro production of IL-6 by PHA-stimulated PBMC of 28 patients was also evaluated. Our data indicate profound alterations in the lymphocyte subpopulations evaluated, including increased CD8 cells (these cells outnumbered CD4 cells in 26 cases), severe defect of CD4 cells (< 400/mm3) in 10 cases and reduction of CD19 cells (< 50/mm3) in 11/41 cases. Increased production in vitro of IL-6 by PBMC of CVI patients does not correlate with the absolute numbers of lymphocytes, lymphocyte subpopulations, or monocytes. In addition, IL-6 was unable to significantly modify the amount of PWM-driven IgM production by CVI cells.

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Immunodeficiency

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