NMDA受体拮抗剂对社会学习的促进作用

Behavioral and neural biology Pub Date : 1993-11-01 DOI:10.1016/0163-1047(93)90409-B

Renate Lederer, Elisabeth Radeke, Cesare Mondadori

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引用次数: 18

摘要

单次口服0.3 mg/kg竞争性NMDA受体阻滞剂CGP 37849可改善大鼠在社会记忆范式中的保留表现。该效应随着剂量的增加而消失:在1 mg/kg时仍可观察到阳性趋势;在3毫克/千克的浓度下，没有检测到任何影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Facilitation of social learning by treatment with an NMDA receptor antagonist

A single oral treatment with 0.3 mg/kg of the competitive NMDA receptor blocker CGP 37 849 improved the retention performance of rats in a social memory paradigm. The effect disappeared with increasing doses: at 1 mg/kg a positive trend could still be observed; at 3 mg/kg no effect whatever was detectable.

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Behavioral and neural biology

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