非免疫功能低下宿主的播散性组织浆菌病。

P Harten, H H Euler, E Wolf, G Delling, H Löffler
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引用次数: 7

摘要

组织浆体感染在欧洲是罕见的,急性播散性组织浆体病只在免疫功能低下的人群中观察到。我们描述一个病例急性播散性组织胞浆菌病在一个年轻的,非免疫功能低下的欧洲妇女。可能的传染源是斯里兰卡或马尔代夫。患者就诊时病情严重,伴有发热、淋巴结病、贫血、血小板减少、肝脾肿大和多发性浆液炎。组织学上,髓外造血观察到骨髓纤维化和骨硬化。用甲基苯丙胺银染色法在骨髓环钻活检组织中检测到荚膜组织浆酵母。常规治疗和两性霉素B脂质体治疗以及随后的伊曲康唑治疗使患者迅速完全康复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disseminated histoplasmosis in a non-immunocompromised host.

Histoplasma infections in Europe are rare, and acute disseminated histoplasmosis has only been observed in immunocompromised persons. We describe a case of acute disseminated histoplasmosis in a young, nonimmunocompromised European woman. The probable source of infection was Sri Lanka or the Maldives. At presentation she was severely ill with fever, lymphadenopathy, anemia, thrombocytopenia, hepatosplenomegaly, and polyserositis. Histologically, myelofibrosis and osteosclerosis were observed with extramedullary hematopoiesis. Histoplasma capsulatum yeasts were detected in bone marrow trephine biopsy by methenamine silver staining. Treatment with conventional and liposomal amphotericin B and subsequent itraconazole led to rapid and complete recovery.

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