H Izumi, S Hirano, Y Matsushita, H Iguchi, H Tone, T Takeuchi
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引用次数: 0
摘要
我们研究了吡柔比星((2 ' R)-4'- o -四氢吡喃ladriamycin, THP)与各种抗肿瘤药物联合治疗P388小鼠白血病的疗效。THP与多种抗肿瘤药物联用，特别是与环磷酰胺(CPM)、顺铂(CDDP)、丝裂霉素C (MMC)、依诺他滨(BHAC)、长春地西(VDS)或甲氨蝶呤(MTX)联用，均显示出较高的抗肿瘤活性。联合治疗的效果取决于THP和联合用药的给药顺序。thp治疗前联合5-氟尿嘧啶(5-FU)或MTX具有更强的协同作用。在thp之前或与ETP同时处理时，显示出比ETP之前更高的协同活性。此外，THP在与CPM、CDDP、MMC、BHAC、VDS或MTX联合的任何顺序中均表现出更高的协同效应。这些结果表明，如果THP与各种抗肿瘤药物联合使用的药物选择和给药顺序合适，THP在临床上具有治疗作用。
Experimental combination chemotherapy of pirarubicin with various antitumor drugs against P388 murine leukemia.
We have examined the therapeutic effects of combination therapy of pirarubicin ((2"R)-4'-O-tetrahydropyranyladriamycin, THP) with various antitumor agents against P388 murine leukemia. THP showed a high antitumor activity in combination with various antitumor drugs, especially with cyclophosphamide (CPM), cisplatin (CDDP), mitomycin C (MMC), enocitabine (BHAC), vindesine (VDS) or methotrexate (MTX). The effects of combination therapy depended on the order of administration of THP and combined drugs. THP-preceding treatment gave more synergistic effects in combination with 5-fluorouracil (5-FU) or MTX. THP-preceding or simultaneous treatment with etoposide (ETP) indicated the higher synergistic activity than ETP-preceding one. Moreover, THP showed much higher synergistic effects in any order of the combination with CPM, CDDP, MMC, BHAC, VDS or MTX. These results suggest that THP possesses a therapeutic usefulness clinically in combination with various antitumor drugs, if the selection of drugs combined with THP and the order of administration are suitable.
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