C.J.M. Rompelberg, W.H. Steinhuis, N. de Vogel, W.A. van Osenbruggen, A. Schouten, H. Verhagen
{"title":"丁香酚在鼠类骨髓微核试验中的抗诱变性","authors":"C.J.M. Rompelberg, W.H. Steinhuis, N. de Vogel, W.A. van Osenbruggen, A. Schouten, H. Verhagen","doi":"10.1016/0165-7992(95)90053-5","DOIUrl":null,"url":null,"abstract":"<div><p>The antimutagenic effect of eugenol on the mutagenicity of cyclophosphamide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[<em>a</em>]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus test using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency of micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a]P. The results provide some support for antimutagenic potency of eugenol in vivo.</p></div>","PeriodicalId":100934,"journal":{"name":"Mutation Research Letters","volume":"346 2","pages":"Pages 69-75"},"PeriodicalIF":0.0000,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-7992(95)90053-5","citationCount":"41","resultStr":"{\"title\":\"Antimutagenicity of eugenol in the rodent bone marrow micronucleus test\",\"authors\":\"C.J.M. Rompelberg, W.H. Steinhuis, N. de Vogel, W.A. van Osenbruggen, A. Schouten, H. Verhagen\",\"doi\":\"10.1016/0165-7992(95)90053-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The antimutagenic effect of eugenol on the mutagenicity of cyclophosphamide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[<em>a</em>]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus test using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency of micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a]P. The results provide some support for antimutagenic potency of eugenol in vivo.</p></div>\",\"PeriodicalId\":100934,\"journal\":{\"name\":\"Mutation Research Letters\",\"volume\":\"346 2\",\"pages\":\"Pages 69-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-7992(95)90053-5\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0165799295900535\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research Letters","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165799295900535","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antimutagenicity of eugenol in the rodent bone marrow micronucleus test
The antimutagenic effect of eugenol on the mutagenicity of cyclophosphamide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[a]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus test using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency of micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a]P. The results provide some support for antimutagenic potency of eugenol in vivo.
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