{"title":"MAP激酶级联在爪蟾卵母细胞中的调控和功能。","authors":"H Kosako, Y Gotoh, E Nishida","doi":"10.1242/jcs.1994.supplement_18.17","DOIUrl":null,"url":null,"abstract":"<p><p>In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.</p>","PeriodicalId":77195,"journal":{"name":"Journal of cell science. Supplement","volume":"18 ","pages":"115-9"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1242/jcs.1994.supplement_18.17","citationCount":"33","resultStr":"{\"title\":\"Regulation and function of the MAP kinase cascade in Xenopus oocytes.\",\"authors\":\"H Kosako, Y Gotoh, E Nishida\",\"doi\":\"10.1242/jcs.1994.supplement_18.17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.</p>\",\"PeriodicalId\":77195,\"journal\":{\"name\":\"Journal of cell science. Supplement\",\"volume\":\"18 \",\"pages\":\"115-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1242/jcs.1994.supplement_18.17\",\"citationCount\":\"33\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cell science. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1242/jcs.1994.supplement_18.17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cell science. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1242/jcs.1994.supplement_18.17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Regulation and function of the MAP kinase cascade in Xenopus oocytes.
In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.
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