米索前列醇对大鼠肠道酶发生的影响。

Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Pub Date : 1994-07-01

A Marti, M J Moreno, M P Fernandez-Otero

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引用次数: 0

摘要

研究了米索前列醇(PGE1类似物)对哺乳大鼠小肠生化变化的影响。米索前列醇增加小肠近端和远端蔗糖酶活性。米索前列醇处理大鼠空肠氨肽酶N活性高于对照组大鼠。这种药物还能改变小肠的相对重量和粘膜中DNA与RNA的比例。米索前列醇效应似乎是由皮质酮释放介导的。

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Effect of misoprostol on the enzyme ontogeny of the rat intestine.

The effect of Misoprostol (an analog of PGE1) on the biochemical changes in the small intestine of suckling rats was studied. Misoprostol increases sucrase activities in the proximal and the distal small intestine. Jejunal aminopeptidase N activity is higher in Misoprostol-treated rats than in the control rats. This drug also modifies the relative weight of the small intestine and the mucosal ratio of DNA to RNA. Misoprostol effects appear to be mediated by corticosterone release.

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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology

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