A.J. van der Westhuijzen BChD, MChD (FFD(SA), FDSRCS(Eng)) , J.A. Roelofse MBChB, MMed, PhD , F.W. Grotepass BChD, MChD (Professor and Head) , P.J. Becker PhD
{"title":"第三磨牙手术后tiaprofenic acid和双氯芬酸钠的随机双盲比较","authors":"A.J. van der Westhuijzen BChD, MChD (FFD(SA), FDSRCS(Eng)) , J.A. Roelofse MBChB, MMed, PhD , F.W. Grotepass BChD, MChD (Professor and Head) , P.J. Becker PhD","doi":"10.1016/0030-4220(94)90165-1","DOIUrl":null,"url":null,"abstract":"<div><p><strong><em>Objective.</em></strong> This study compares the effectiveness of tiaprofenic acid with diclophenac sodium over a 7-day period with respect to pain, facial swelling, and trismus.</p><p><strong><em>Study design.</em></strong> Sixty patients who required general anesthesia for removal of bilateral impacted third molar teeth were included. Intraoperatively, they received intramuscular injections of either tiaprofenic acid or diclophenac sodium followed respectively by tiaprofenic acid tablets for 5 days and placebo for an additional 2 days or diclophenac sodium tablets for the full 7 days. Surgical and anesthetic techniques were standardized. Pain levels were compared hourly for 4 hours postoperatively and thereafter twice daily for 7 days. Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively.</p><p><strong><em>Results.</em></strong> No statistically significant difference was found between the two treatment groups with respect to pain or facial swelling. Only with respect to recovery in mouth-opening ability (trismus) from day 2 to day 7 did diclophenac sodium reveal a statistically significant advantage (<em>p</em> = 0.0452).</p></div>","PeriodicalId":100992,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology","volume":"78 5","pages":"Pages 557-566"},"PeriodicalIF":0.0000,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0030-4220(94)90165-1","citationCount":"30","resultStr":"{\"title\":\"Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery\",\"authors\":\"A.J. van der Westhuijzen BChD, MChD (FFD(SA), FDSRCS(Eng)) , J.A. Roelofse MBChB, MMed, PhD , F.W. Grotepass BChD, MChD (Professor and Head) , P.J. Becker PhD\",\"doi\":\"10.1016/0030-4220(94)90165-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><strong><em>Objective.</em></strong> This study compares the effectiveness of tiaprofenic acid with diclophenac sodium over a 7-day period with respect to pain, facial swelling, and trismus.</p><p><strong><em>Study design.</em></strong> Sixty patients who required general anesthesia for removal of bilateral impacted third molar teeth were included. Intraoperatively, they received intramuscular injections of either tiaprofenic acid or diclophenac sodium followed respectively by tiaprofenic acid tablets for 5 days and placebo for an additional 2 days or diclophenac sodium tablets for the full 7 days. Surgical and anesthetic techniques were standardized. Pain levels were compared hourly for 4 hours postoperatively and thereafter twice daily for 7 days. Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively.</p><p><strong><em>Results.</em></strong> No statistically significant difference was found between the two treatment groups with respect to pain or facial swelling. Only with respect to recovery in mouth-opening ability (trismus) from day 2 to day 7 did diclophenac sodium reveal a statistically significant advantage (<em>p</em> = 0.0452).</p></div>\",\"PeriodicalId\":100992,\"journal\":{\"name\":\"Oral Surgery, Oral Medicine, Oral Pathology\",\"volume\":\"78 5\",\"pages\":\"Pages 557-566\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0030-4220(94)90165-1\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery, Oral Medicine, Oral Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0030422094901651\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery, Oral Medicine, Oral Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0030422094901651","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery
Objective. This study compares the effectiveness of tiaprofenic acid with diclophenac sodium over a 7-day period with respect to pain, facial swelling, and trismus.
Study design. Sixty patients who required general anesthesia for removal of bilateral impacted third molar teeth were included. Intraoperatively, they received intramuscular injections of either tiaprofenic acid or diclophenac sodium followed respectively by tiaprofenic acid tablets for 5 days and placebo for an additional 2 days or diclophenac sodium tablets for the full 7 days. Surgical and anesthetic techniques were standardized. Pain levels were compared hourly for 4 hours postoperatively and thereafter twice daily for 7 days. Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively.
Results. No statistically significant difference was found between the two treatment groups with respect to pain or facial swelling. Only with respect to recovery in mouth-opening ability (trismus) from day 2 to day 7 did diclophenac sodium reveal a statistically significant advantage (p = 0.0452).
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