主动脉瘤修复术后出血

Alan A. Milne , William G. Murphy , Andrew W. Bradbury , C. Vaughan Ruckley
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引用次数: 15

摘要

在1988年至1993年期间,总共654例患者中有17例(3%)在血管外科单元进行腹主动脉瘤修复后再次手术以控制出血。12例因破裂行首次手术,5例选择性手术。择期手术后再手术出血发生率为1.7%,急诊手术后再手术出血发生率为3.3%。确定了与性别和原发手术相匹配的病例对照。再次手术死亡率为58%,对照组为23% (p = 0.037)。7例患者病情进行性恶化,术后早期死亡。在剩下的10例患者中,有4例出现了意想不到的严重并发症;2例为致死性脑血管意外(CVA), 1例为致死性心肌梗死(MI), 4例为非致死性脑血管意外(CVA)。需要再次手术的患者出血量较大(p <0.05),更大的输血需求和更低的核心温度(p <第一次手术结束时与对照组比较,差异无统计学意义(0.05)。除1例出血患者外,所有出血患者在第一次手术前后均有凝血功能障碍的迹象,血小板计数低于对照组。再次手术时,11例患者出现多个小出血点,2例患者无活动性出血点,4例患者出现离散性出血点。总之,再次手术控制术后出血是一种罕见的并发症,与凝血功能密切相关,可能易发生术后“反弹”血栓发作,预后较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Postoperative haemorrhage following aortic aneurysm repair

Between 1988 and 1993, 17 (3%) out of a total 654 patients underwent reoperation for control of haemorrhage following repair of abdominal aortic aneurysm in a vascular surgery unit. The first operation was performed for rupture in 12 cases and electively in five. The incidence of reoperation for postoperative bleeding was 1.7% following elective operation and 3.3% following emergency operation. Case-controls, matched for sex and primary operation, were identified. The mortality rate in those requiring reoperation was 58% compared with 23% in the control group (p = 0.037). Seven patients suffered progressive deterioration and died in the early postoperative period. Of the remaining ten patients, four suffered unexpected serious complications; two a fatal cerebro-vascular accident (CVA), one a fatal myocardial infarction (MI) and the fourth a non-fatal CVA. The patients requiring reoperation had greater blood loss (p < 0.05), greater transfusion requirements and lower core temperatures (p < 0.05) at the end of their first operation than the control group. All except one of the patients who bled had evidence of coagulopathy and had lower platelet counts than the control group both before and after the first operation. At reoperation there were multiple minor bleeding points in 11 patients, no active bleeding points in two patients and a discrete bleeding point in four patients. In conclusion, re-operation for control of postoperative haemorrhage is an uncommon complication which is strongly associated with coagulopathy, may predispose to “rebound” postoperative thrombotic episodes, and carries a poor prognosis.

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