Sol Silverman Jr MA DDS (Professor) , George E. Kaugars DDS (Professor) , John Gallo MT (Certified Medical Technologist) , Joan S. Thompson PhD, RD (Assistant Professor) , Daniel P. Stites MD (Professor and Chair) , William T. Riley PhD (Associate Professor) , Richard B. Brandt PhD (Professor)
{"title":"11例慢性口腔念珠菌病hiv阳性患者补充β -胡萝卜素的临床和淋巴细胞反应","authors":"Sol Silverman Jr MA DDS (Professor) , George E. Kaugars DDS (Professor) , John Gallo MT (Certified Medical Technologist) , Joan S. Thompson PhD, RD (Assistant Professor) , Daniel P. Stites MD (Professor and Chair) , William T. Riley PhD (Associate Professor) , Richard B. Brandt PhD (Professor)","doi":"10.1016/0030-4220(94)90035-3","DOIUrl":null,"url":null,"abstract":"<div><p>Eleven HIV-positive patients with chronic oral candidiasis were supplemented with 60 to 120 mg of beta-carotene daily for 3 to 7 months. Lymphocyte profiles were evaluated at intervals to help assess immune competence. Although there was a modest increase in some lymphocyte values at 2 months, there was a significant decrease in numbers of CD4 and CD8 cells and CD4 percentage of lymphocytes after 6 months of beta-carotene supplementation. Serum triglyceride and liver enzyme levels were not affected by the beta-carotene supplementation. No improvement was observed in the control of the oral candidiasis. Under the conditions of the study, there was no indication that daily beta-carotene supplements enhanced immune competence or was of benefit in managing oral candidiasis.</p></div>","PeriodicalId":100992,"journal":{"name":"Oral Surgery, Oral Medicine, Oral Pathology","volume":"78 4","pages":"Pages 442-447"},"PeriodicalIF":0.0000,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0030-4220(94)90035-3","citationCount":"16","resultStr":"{\"title\":\"Clinical and lymphocyte responses to beta-carotene supplementation in 11 HIV-positive patients with chronic oral candidiasis\",\"authors\":\"Sol Silverman Jr MA DDS (Professor) , George E. Kaugars DDS (Professor) , John Gallo MT (Certified Medical Technologist) , Joan S. Thompson PhD, RD (Assistant Professor) , Daniel P. Stites MD (Professor and Chair) , William T. Riley PhD (Associate Professor) , Richard B. Brandt PhD (Professor)\",\"doi\":\"10.1016/0030-4220(94)90035-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Eleven HIV-positive patients with chronic oral candidiasis were supplemented with 60 to 120 mg of beta-carotene daily for 3 to 7 months. Lymphocyte profiles were evaluated at intervals to help assess immune competence. Although there was a modest increase in some lymphocyte values at 2 months, there was a significant decrease in numbers of CD4 and CD8 cells and CD4 percentage of lymphocytes after 6 months of beta-carotene supplementation. Serum triglyceride and liver enzyme levels were not affected by the beta-carotene supplementation. No improvement was observed in the control of the oral candidiasis. Under the conditions of the study, there was no indication that daily beta-carotene supplements enhanced immune competence or was of benefit in managing oral candidiasis.</p></div>\",\"PeriodicalId\":100992,\"journal\":{\"name\":\"Oral Surgery, Oral Medicine, Oral Pathology\",\"volume\":\"78 4\",\"pages\":\"Pages 442-447\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0030-4220(94)90035-3\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral Surgery, Oral Medicine, Oral Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0030422094900353\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery, Oral Medicine, Oral Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0030422094900353","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical and lymphocyte responses to beta-carotene supplementation in 11 HIV-positive patients with chronic oral candidiasis
Eleven HIV-positive patients with chronic oral candidiasis were supplemented with 60 to 120 mg of beta-carotene daily for 3 to 7 months. Lymphocyte profiles were evaluated at intervals to help assess immune competence. Although there was a modest increase in some lymphocyte values at 2 months, there was a significant decrease in numbers of CD4 and CD8 cells and CD4 percentage of lymphocytes after 6 months of beta-carotene supplementation. Serum triglyceride and liver enzyme levels were not affected by the beta-carotene supplementation. No improvement was observed in the control of the oral candidiasis. Under the conditions of the study, there was no indication that daily beta-carotene supplements enhanced immune competence or was of benefit in managing oral candidiasis.
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