人与猪食管膜酶的比较猪食道是研究人类食道的一个很好的模型。

The Histochemical Journal Pub Date : 1995-03-01
K N Christie, C Thomson, D Hopwood
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引用次数: 0

摘要

测定了5种质膜酶(碱性磷酸酶、二肽基肽酶IV、γ -谷氨酰转肽酶、微粒体丙氨酰氨基肽酶和谷氨酰氨基肽酶)在人和猪食管中的分布和相对催化活性。在这两个物种中,碱性磷酸酶活性发生在上皮的基底细胞和上基底细胞以及毛细血管中。人粘膜下层的基质细胞反应性特别强。二肽基肽酶IV存在于人和猪的血管和毛细血管以及猪的粘膜下腺中。该酶也存在于两种紧挨着上皮基底层的固有层细胞中。在人类中,γ -谷氨酰转肽酶发生在上皮基底细胞和猪分离的基底细胞和下棘细胞中。人粘膜下层的基质细胞反应强烈,两种动物固有肌层的毛细血管有中度活性。在人和猪上皮基底细胞层附近的固有层细胞和猪粘膜下腺的粘膜细胞顶端检测到微粒体丙氨酰氨基肽酶。弱谷氨酰氨基肽酶活性局限于毛细血管。这项研究的结果,加上猪食道的现成可用性,表明猪可能是研究人类食道的合适模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparison of membrane enzymes of human and pig oesophagus; the pig oesophagus is a good model for studies of the gullet in man.

The distribution and relative catalytic activities of five plasma membrane enzymes (alkaline phosphatase, dipeptidyl peptidase IV, gamma-glutamyl transpeptidase, microsomal alanyl aminopeptidase and glutamyl aminopeptidase) were examined in human and pig oesophagus. In both species, alkaline phosphatase activity occurred in basal and suprabasal cells of the epithelium and in capillaries. Stromal cells in the human submucosa were particularly reactive. Dipeptidyl peptidase IV was present in blood vessels and capillaries in man and pig and in submucous glands in the pig. The enzyme was also present in both species in the lamina propria cells immediately adjacent to the epithelial basal lamina. In the human, gamma-glutamyl transpeptidase occurred in the epithelial basal cells and in isolated basal and lower prickle cells in the pig. Stromal cells in the human submucosa were strongly reactive and capillaries in the muscularis propria in both species moderately active. Microsomal alanyl aminopeptidase was detected in lamina propria cells adjacent to the epithelial basal cell layer in man and pig and at the apices of mucous cells in pig submucous glands. Weak glutamyl aminopeptidase activity was confined to capillaries in both species. The findings of this study, along with the ready availability of pig oesophagus, suggest that the pig may be a suitable model for studies of the gullet in man.

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