对照组外周血淋巴细胞的染色体畸变

Mutation Research Letters Pub Date : 1995-04-01 DOI:10.1016/0165-7992(95)90034-9

Vilena Kašuba, Karmela Šentija, Vera Garaj-Vrhova, Aleksandra Fučić

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引用次数: 37

摘要

本研究强调在获得适当的控制水平以与职业性接触致裂原的研究进行比较时所遇到的问题。从135个人(69名女性和66名男性)中采集血样，检查染色体畸变。数据包括15368个染色体畸变细胞。测定染色单体和染色体断裂、无中心片段和双中心片段的频率。最常见的染色体畸变，染色体断裂的频率为1.1 x 10-2, dicentries的频率为0.26 x 103。结果与性别、吸烟习惯、诊断性x射线暴露和抗生素使用有关。各项参数均无显著性差异。

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Chromosome aberrations in peripheral blood lymphocytes from control individuals

This study emphasizes the problems encountered in obtaining suitable contol levels for comparison with occupational studies of exposure to clastogens.

Blood samples taken from 135 individuals (69 females and 66 males) were examined for chromosome aberrations. The data include 15 368 cells scored for chromosome aberrations. The frequencies of chromatid and chromosome breaks, acentric fragments and dicentrics were determined. The frequency of the most common chromosome aberration, chromosome breaks, was 1.1 x 10^-2 and for dicentries 0.26 x 10³. The values obtained were investigatd in relation to sex, cigarette smoking habits, diagnostic X-ray exposure and use of antibiotics. In all the parameters, no significant differences were found.

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Mutation Research Letters

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