{"title":"真性性早熟与苯丙酮尿症有关。","authors":"B Büyükgebiz, Y Eroğlu, A Büy ukgebiz","doi":"10.1515/jpem.1994.7.4.361","DOIUrl":null,"url":null,"abstract":"<p><p>We studied a girl with phenylketonuria who demonstrated signs of precocious puberty. At the age of 7.5 years she had premature telarche. Her height age was 7-9/12 years and her bone age was 9 years. Gonadotropin responses to LHRH administration were consistent with central precocious puberty. Elevated serum phenylalanine levels in this patient, due to poor compliance with the phenylalanine restricted diet, may be related to the early onset of puberty.</p>","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"7 4","pages":"361-3"},"PeriodicalIF":0.0000,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1994.7.4.361","citationCount":"5","resultStr":"{\"title\":\"True precocious puberty associated with phenylketonuria.\",\"authors\":\"B Büyükgebiz, Y Eroğlu, A Büy ukgebiz\",\"doi\":\"10.1515/jpem.1994.7.4.361\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We studied a girl with phenylketonuria who demonstrated signs of precocious puberty. At the age of 7.5 years she had premature telarche. Her height age was 7-9/12 years and her bone age was 9 years. Gonadotropin responses to LHRH administration were consistent with central precocious puberty. Elevated serum phenylalanine levels in this patient, due to poor compliance with the phenylalanine restricted diet, may be related to the early onset of puberty.</p>\",\"PeriodicalId\":79383,\"journal\":{\"name\":\"The Journal of pediatric endocrinology\",\"volume\":\"7 4\",\"pages\":\"361-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1515/jpem.1994.7.4.361\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of pediatric endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/jpem.1994.7.4.361\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of pediatric endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jpem.1994.7.4.361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
True precocious puberty associated with phenylketonuria.
We studied a girl with phenylketonuria who demonstrated signs of precocious puberty. At the age of 7.5 years she had premature telarche. Her height age was 7-9/12 years and her bone age was 9 years. Gonadotropin responses to LHRH administration were consistent with central precocious puberty. Elevated serum phenylalanine levels in this patient, due to poor compliance with the phenylalanine restricted diet, may be related to the early onset of puberty.
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