牛生长激素对小鼠胸腺退化模式的影响。

Thymus Pub Date : 1994-01-01

Y Bar-Dayan, M Small

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引用次数: 0

摘要

通过反复注射牛生长激素，小鼠胸腺与年龄相关的衰退得以逆转。在5、8或11.5月龄时开始给药后，皮质体积分数(Vc)、皮质/髓质比(C/M)和胸腺细胞数量均在幼年小鼠的范围内。注射生长激素降低了Vc和C/M随年龄变化曲线的斜率，表明衰老过程减缓。

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Effect of bovine growth hormone administration on the pattern of thymic involution in mice.

Age-related decline of the thymus in mice was reversed by repeated injections of bovine growth hormone. After hormone administration that was begun at 5, 8, or 11.5 months of age, the cortical volume fraction (Vc), cortical/medullary ratio (C/M) and thymocyte numbers found were in the range obtained with younger mice. Growth hormone injection reduced the slope of the curves for Vc and C/M as a function of age, indicating a slowing down of the involution process.

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Thymus

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