R K Fuller, M E Mattson, J P Allen, C L Randall, R F Anton, T F Babor
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Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.
Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
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