强化胰岛素治疗组1型糖尿病患者血糖水平的变异性

Diabete & metabolisme Pub Date : 1994-11-01
E A Moberg, P E Lins, U K Adamson
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引用次数: 0

摘要

本研究的目的是寻找98例1型糖尿病患者的血糖变异性与24项临床参数之间可能的联系,这些患者接受多次胰岛素注射或胰岛素泵治疗,并进行自我血糖监测。血糖变异性以每两天在五个指定时间点自我监测获得的血糖值的标准偏差来测量,持续四周。血糖变异性与平均血糖水平(r = 0.48, p = 0.0001)和低血糖事件次数(r = 0.31, p = 0.002)显著相关,但与糖化血红蛋白无关(r = 0.19, p = 0.07)。血糖变异性与患者胰岛素剂量变化(r = 0.31, p = 0.004)、糖尿病病程(r = 0.22, p = 0.03)和体重指数(r = 0.20, p = 0.04)之间也存在显著相关性。与无肾病体征的患者相比,早期或临床肾病患者的血糖值变化更多(p = 0.03)。研究的其他参数,如其他晚期糖尿病并发症、c肽水平、胰岛素剂量和胰岛素结合抗体水平与血糖变异性无显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variability of blood glucose levels in patients with type 1 diabetes mellitus on intensified insulin regimens.

The aim of the present study was to look for possible associations between the blood glucose variability and twenty-four clinical parameters in ninety-eight patients with Type 1 diabetes mellitus treated with multiple injections of insulin or insulin pumps and practising self-monitoring of blood glucose. The blood glucose variability was measured as the standard deviation of glucose values obtained by self-monitoring at five specified time points every two days for four weeks. The blood glucose variability significantly correlated with the mean blood glucose level (r = 0.48, p = 0.0001) and with the number of hypoglycaemic events (r = 0.31, p = 0.002), but not with HbA1c (r = 0.19, p = 0.07). Significant correlations were also found between glucose variability and patients' variations of insulin dosage (r = 0.31, p = 0.004), duration of diabetes (r = 0.22, p = 0.03), and body-mass index (r = 0.20, p = 0.04). Patients with incipient or clinical nephropathy had more variable blood glucose values, compared with patients without signs of nephropathy (p = 0.03). Other parameters studied, such as other late diabetic complications, the C-peptide level, the insulin dose and the level of insulin-binding to antibodies did not relate significantly to the blood glucose variability.

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