慢性胰腺炎所致糖尿病患者下肢动脉病变。

Diabete & metabolisme Pub Date : 1994-11-01
O Ziegler, H Candiloros, B Guerci, I Got, T Crea, P Drouin
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引用次数: 0

摘要

目的:了解胰型糖尿病患者下肢动脉病变的发生率及动脉梗阻部位。患者和方法:回顾性研究纳入83例慢性胰腺炎糖尿病患者(年龄[m +/- SD] 54.5 +/- 9.5年,糖尿病病程9.7 +/- 7.4年)和83例特发性糖尿病患者,对性别、年龄、糖尿病病程和治疗进行了仔细匹配。他们通过节段血压和多普勒超声筛查动脉病变,以及心血管危险因素。动脉病变分为近端(膝上)、远端(膝下)和合并(膝上和膝下)。结果:下肢动脉病变发生率为25.3%的胰腺炎患者和14.5%的特发性糖尿病患者(p = 0.08)。两组梗阻部位相似;近端梗阻:4例vs 4例;远端:10例vs 5例,合并:7例vs 3例。两组动脉病变患病率均随年龄和糖尿病病程增加而增加(p < 0.01)。胰腺炎患者总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B明显降低(p < 0.01);其中92%为吸烟者,62%为特发性糖尿病患者(p < 0.001)。结论:动脉病变,通过非侵入性检查评估,在慢性胰腺炎和特发性糖尿病患者中具有相同的患病率和分布,尽管他们的血管危险因素不同。这强调了慢性高血糖及其持续时间在糖尿病患者大血管病变发病机制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lower-extremity arterial disease in diabetes mellitus due to chronic pancreatitis.

Objective: To determine the prevalence of lower-extremity arterial disease and the sites of arterial obstruction in patients with pancreatic diabetes.

Patients and methods: The retrospective study included 83 patients with diabetes due to chronic pancreatitis (age [m +/- SD] 54.5 +/- 9.5 yr, diabetes duration 9.7 +/- 7.4 yr) and 83 patients with idiopathic diabetes were carefully matched for sex, age, diabetes duration and treatment. They were screened for arteriopathy by segmental blood pressures and Doppler ultrasound, and for cardiovascular risk factors. The arterial lesions were classified as proximal (above-knee), distal (below-knee), and combined (both above- and below-knee).

Results: Lower extremity arterial disease occurred in 25.3% of pancreatitis patients and in 14.5% of idiopathic diabetes patients (p = 0.08). The sites of obstruction in both groups were similar; proximal obstruction: 4 vs 4 cases; distal: 10 vs 5 cases, combined: 7 vs 3 cases. The prevalence of arteriopathy increased with age and diabetes duration in both groups (p < 0.01). Total cholesterol, LDL cholesterol and apolipoprotein B were lower in the pancreatitis patients (p < 0.01); 92% of these were smokers vs 62% of idiopathic diabetes patients (p < 0.001).

Conclusions: Arteriopathy, assessed by non-invasive tests, has the same prevalence and distribution in chronic pancreatitis and idiopathic diabetes patients, despite their different vascular risk factor profiles. This emphasizes the role of chronic hyperglycaemia and its duration in the pathogenesis of macroangiopathy in diabetic patients.

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