匹洛卡平对眼液中左旋布诺尔吸收的影响。

D D Tang-Liu, J B Richman
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引用次数: 1

摘要

在体外和体内研究了匹罗卡品对左旋布诺洛尔眼部吸收的影响。左炔布洛尔的眼部吸收是ph依赖性的。由于pH值为5.5时匹罗卡品的缓冲能力大,在pH值为7.2时,与不含匹罗卡品的制剂相比,含匹罗卡品溶液中左旋布诺洛尔的眼部吸收减少了大约四倍。在酸性pH值下,在匹洛卡平存在的情况下,左旋布诺洛尔的眼部吸收通过使用琥珀酸盐,特别是Schercopol CMS而增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of pilocarpine on ocular levobunolol absorption from ophthalmic solutions.

Studies in vitro and in vivo were conducted to investigate the effect of pilocarpine on ocular absorption of levobunolol when both drugs were formulated in one solution dosage. The ocular absorption of levobunolol is pH-dependent. Due to the large buffering capacity of pilocarpine at pH 5.5, the ocular absorption of levobunolol from pilocarpine-containing solutions was reduced by approximately four-fold as compared to a non-pilocarpine-containing formulation at pH 7.2. The ocular absorption of levobunolol in the presence of pilocarpine at acidic pH was enhanced by the use of sulfosuccinates, specifically Schercopol CMS.

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