1型糖尿病患者Lp(a)颗粒水平与白蛋白排泄率之间缺乏相关性。

Diabete & metabolisme Pub Date : 1994-11-01
B Guerci, B Igau, O Ziegler, T Crea, J C Fruchart, P Drouin, C Fievet
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引用次数: 0

摘要

与非糖尿病患者相比,1型糖尿病患者发生心血管疾病的风险过高,这只能部分地用标准危险因素来解释。一些研究表明,Lp(a)浓度在1型糖尿病中升高,但数据仍有争议。此外,持续蛋白尿的糖尿病患者有较高的心血管风险。因此,本研究的目的是比较有或没有尿白蛋白排泄增加的胰岛素依赖型糖尿病患者的Lp(a)颗粒水平。140例胰岛素依赖型糖尿病患者血浆Lp(a)水平横断面研究:83例无蛋白尿增高,14例尿白蛋白排泄边缘性增高,27例微量蛋白尿,16例大量蛋白尿。同时测定血脂、空腹血糖和糖化血红蛋白。所有糖尿病患者组的平均血浆Lp(a)浓度及其水平分布具有可比性。Lp(a)与HbA1c、空腹血糖或任何血脂水平没有关系。未观察到白蛋白排泄率对Lp(a)水平的影响。这些数据没有提供Lp(a)颗粒对肾病患者心血管疾病发病率和死亡率增加的具体贡献的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lack of relationship between Lp(a) particle levels and albumin excretion rate in type 1 diabetic patients.

The excess risk of cardiovascular disease in Type 1 diabetes mellitus compared to non diabetic subjects is only partially explained by standard risk factors. Several studies suggest that Lp(a) concentrations are increased in Type 1 diabetes mellitus, but data are still controversial. Moreover, a high cardiovascular risk has been reported in diabetic patients with persistent proteinuria. Therefore, the aim of this study was to compare the Lp(a) particle levels in insulin-dependent diabetic patients with or without increased urinary albumin excretion. Cross-sectional study of Lp(a) plasma levels in a population of 140 insulin-dependent diabetic patients: 83 without increased proteinuria, 14 with borderline elevation of urinary albumin excretion, 27 with micro- and 16 with macro-proteinuria. Simultaneous determination of plasma lipids, fasting blood glucose and HbA1c was performed. The mean plasma Lp(a) concentrations and the distribution of the levels were comparable in all of the diabetic patient groups. No relationship existed between Lp(a) and HbA1c, fasting blood glucose or any lipid plasma levels. No influence of albumin excretion rate on Lp(a) levels was observed. These data provide no evidence of a specific contribution of Lp(a) particles to the increased morbidity and mortality from cardiovascular disease observed among patients with nephropathy.

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