低血糖,胰岛素治疗最可怕的并发症。

Diabete & metabolisme Pub Date : 1994-11-01
R J McCrimmon, B M Frier
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引用次数: 0

摘要

胰岛素诱导的低血糖是胰岛素治疗最常见的副作用,是相当高发病率的潜在来源,并具有公认的死亡率。急性低血糖产生强烈的生理应激,伴随深刻的交感肾上腺刺激和激素反调节系统的广泛激活,导致继发性血流动力学和血液流变学改变。急性和复发性严重低血糖的临床影响与显著的发病率相关,包括可逆的和永久性的心血管、神经和认知功能异常,以及创伤和道路交通事故。如果要限制胰岛素治疗这种危险副作用的发生频率和不良反应,那么在设计胰岛素治疗方案和确定个体患者的治疗目标时,了解低血糖的发病率是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoglycaemia, the most feared complication of insulin therapy.

Insulin-induced hypoglycaemia, the most frequent side-effect of insulin-therapy, is a potential source of considerable morbidity and has a recognised mortality. Acute hypoglycaemia produces an intense physiological stress with profound sympathoadrenal stimulation and widespread activation of hormonal counterregulatory systems, leading to secondary haemodynamic and haemorheological changes. The clinical effects of acute and recurrent severe hypoglycaemia are associated with significant morbidity including reversible, and permanent, abnormalities of cardiovascular, neurological and cognitive function, in addition to trauma and road traffic accidents. Comprehension of the morbidity of hypoglycaemia is important when designing insulin regimens and determining therapeutic goals for individual patients if the frequency and adverse effects of this dangerous side-effect of insulin therapy are to be limited.

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