普伐他汀和吉非齐治疗家族性载脂蛋白B-100缺陷患者:一项两期交叉研究

P S Hansen, H Meinertz, L U Gerdes, I C Klausen, O Faergeman
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引用次数: 6

摘要

30例家族性载脂蛋白B-100缺陷患者接受普伐他汀和吉非齐齐两期(各8周)交叉治疗。普伐他汀可使胆固醇、低密度脂蛋白胆固醇和载脂蛋白B降低20-25% (P < 10(-4)),吉非齐可降低4-6%(普伐他汀vs吉非齐可降低P < 10(-4))。对普伐他汀的反应是可变的,与性别、年龄或载脂蛋白E基因型无关。吉非罗齐降低甘油三酯25% (P < 10(-4)),升高高密度脂蛋白胆固醇11%。普伐他汀对这两个相关变量的影响明显较小。两种药物均可显著提高Lp(a)约10%。普伐他汀在FDB患者中的低密度脂蛋白胆固醇降低效果与家族性高胆固醇血症患者相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of patients with familial defective apolipoprotein B-100 with pravastatin and gemfibrozil: a two-period cross-over study.

Thirty patients with familial defective apolipoprotein B-100 were treated in a two-period (8 weeks each) cross-over study with pravastatin and gemfibrozil. Cholesterol, LDL cholesterol, and apo B were reduced by 20-25% (P < 10(-4)) by pravastatin and by 4-6% by gemfibrozil (pravastatin vs. gemfibrozil: P < 10(-4)). Response to pravastatin was variable and not correlated to gender, age, or apo E genotype. Gemfibrozil lowered triglycerides by 25% (P < 10(-4)) and raised HDL cholesterol by 11%. The effects of pravastatin on these two interrelated variables were significantly smaller. Both drugs increased Lp(a) significantly by about 10%. The LDL cholesterol lowering effect of pravastatin in patients with FDB is similar to that observed in patients with familial hypercholesterolemia.

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