{"title":"蒽醌类化合物在V79和三种表达P450酶的衍生细胞系中的致裂性","authors":"S. Simi, S. Monrelli, P.G. Gervasi, G. Rainaldi","doi":"10.1016/0165-7992(95)00034-8","DOIUrl":null,"url":null,"abstract":"<div><p>The clastrogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The result have shown that chromosomal aberrations are modulated in similar manner both in parenal and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.</p></div>","PeriodicalId":100934,"journal":{"name":"Mutation Research Letters","volume":"347 3","pages":"Pages 151-156"},"PeriodicalIF":0.0000,"publicationDate":"1995-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-7992(95)00034-8","citationCount":"12","resultStr":"{\"title\":\"Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes\",\"authors\":\"S. Simi, S. Monrelli, P.G. Gervasi, G. Rainaldi\",\"doi\":\"10.1016/0165-7992(95)00034-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The clastrogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The result have shown that chromosomal aberrations are modulated in similar manner both in parenal and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.</p></div>\",\"PeriodicalId\":100934,\"journal\":{\"name\":\"Mutation Research Letters\",\"volume\":\"347 3\",\"pages\":\"Pages 151-156\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-7992(95)00034-8\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0165799295000348\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research Letters","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165799295000348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes
The clastrogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The result have shown that chromosomal aberrations are modulated in similar manner both in parenal and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.
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