转基因小鼠脾脏lacZ基因自发突变频率随年龄增加而增加

Mutation Research/DNAging Pub Date : 1995-10-01 DOI:10.1016/0921-8734(95)00023-Y

T. Ono , Y. Miyamura , H. Ikehata , H. Yamanaka , A. Kurishita , K. Yamamoto , T. Suzuki , T. Nohmi , M. Hayashi , T. Sofuni

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引用次数: 45

摘要

检测转基因Muta™小鼠在不同年龄时脾脏lacZ基因的自发突变频率。新生儿时为(3.2±1.3 (SD)) × 10 - 5，随着年龄的增长几乎呈线性增长，1岁时达到(8.3±1.8)× 10 - 5。由于基因的突变不太可能在体内受到选择的影响，因此数据支持这样的观点，即自发突变发生在整个衰老过程中，如果不是因细胞死亡而被淘汰，则会随着年龄的增长而积累。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta^™ mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10⁻⁵ at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10⁻⁵ at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.

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Mutation Research/DNAging

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