唾液腺小管腺瘤的免疫组织化学分析

Oral Surgery, Oral Medicine, Oral Pathology Pub Date : 1994-12-01 DOI:10.1016/0030-4220(94)90093-0

Jorge A. Ferreiro MD

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引用次数: 34

摘要

腺管腺瘤是新近发现的涎腺腺瘤，常与恶性涎腺肿瘤混淆。为了更好地表征该肿瘤，我们对6例患者进行了免疫组化抗体检测，包括抗角蛋白(AE1AE3)、抗上皮膜抗原、抗癌胚抗原、抗vimentin、抗s -100、抗肌肉特异性肌动蛋白和抗胶质原纤维酸蛋白。所有小管腺瘤均以类似方式染色，显示抗角蛋白、抗静脉蛋白和抗s -100阳性染色(6例中各6例)。罕见的局灶性抗上皮膜抗原和抗胶质原纤维酸蛋白染色(6例中各1例)。这种免疫组织化学染色模式与成釉细胞瘤、多形性低级别腺癌和腺样囊性癌相比较。免疫组织化学可能有助于区分腺管腺瘤与其他唾液腺肿瘤。

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Immunohistochemical analysis of salivary gland canalicular adenoma

Canalicular adenoma is a newly recognized salivary gland adenoma that may be confused with malignant salivary gland tumors. To better characterize this neoplasm, six examples were investigated with a panel of immunohistochemistry antibodies including anti-keratin ( $AE1 AE3$ ), anti-epithelial membrane antigen, anti-carcinoembryonic antigen, anti-vimentin, anti-S-100, anti-muscle specific actin, and anti-glial fibrillary acid protein. All canalicular adenomas stained in a similar fashion showing positive staining with anti-keratin, anti-vimentin, and anti-S-100 (6 of 6 cases each). Rare focal staining with anti-epithelial membrane antigen and anti-glial fibrillary acid protein was noted (1 of 6 cases each). This immunohistochemistry staining pattern was compared with those of ameloblastoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. Immunohistochemistry may be useful in the distinction of canalicular adenoma from other salivary gland tumors.

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Oral Surgery, Oral Medicine, Oral Pathology

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