免疫耐受:发展和破坏。

Hospital practice (Office ed.) Pub Date : 1995-02-15 DOI:10.1080/21548331.1995.11443152

W O Weigle

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引用次数: 14

摘要

对自身抗原的耐受性丧失被认为在多种常见疾病中起作用。在系统性红斑狼疮等疾病的动物模型中进行的研究为自我耐受性如何被破坏或绕过以及如何恢复提供了新的见解。这些实验和其他实验也阐明了自我容忍通常是如何建立起来的;T淋巴细胞似乎是主要的参与者。

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Immunologic tolerance: development and disruption.

Loss of tolerance to self-antigens is thought to have a role in a variety of common diseases. Studies in animal models of such diseases as systemic lupus erythematosus have provided new insights into how self-tolerance is broken or bypassed and how it may be restored. These and other experiments also are clarifying how self-tolerance is normally established; the T lymphocyte appears to be the dominant player.

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Hospital practice (Office ed.)

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