{"title":"水浸应激诱导大鼠热休克蛋白及预防小蛋白诱导的胰腺炎","authors":"Mlchiro Otaka , Hldeaki Itoh , Toshiyuki Kuwabara , Akira Zeniya , Shusei Fujimori , Setsuya Otani , Yohtalou Tashima , Osamu Masamune","doi":"10.1016/0020-711X(94)90110-4","DOIUrl":null,"url":null,"abstract":"<div><p>Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. The effects of pre-treatment with water-immersion to caerulein-induced pancreatitis were investigated in this study. </p><ul><li><span>1.</span><span><p>1. A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas.</p></span></li><li><span>2.</span><span><p>2. Intra-peritoneal injection of caerulein (40 μg/kg) induced acute pancreatitis in rats without pre-treatment with water-immersion. However, when the rats were pre-treated with water-immersion, acute pancreatitis was not developed and no change of serum amylase levels was observed by i.p. injection of caerulein.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 6","pages":"Pages 805-811"},"PeriodicalIF":0.0000,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90110-4","citationCount":"55","resultStr":"{\"title\":\"Induction of heat shock protein and prevention of caerulein-induced pancreatitis by water-immersion stress in rats\",\"authors\":\"Mlchiro Otaka , Hldeaki Itoh , Toshiyuki Kuwabara , Akira Zeniya , Shusei Fujimori , Setsuya Otani , Yohtalou Tashima , Osamu Masamune\",\"doi\":\"10.1016/0020-711X(94)90110-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. The effects of pre-treatment with water-immersion to caerulein-induced pancreatitis were investigated in this study. </p><ul><li><span>1.</span><span><p>1. A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas.</p></span></li><li><span>2.</span><span><p>2. Intra-peritoneal injection of caerulein (40 μg/kg) induced acute pancreatitis in rats without pre-treatment with water-immersion. However, when the rats were pre-treated with water-immersion, acute pancreatitis was not developed and no change of serum amylase levels was observed by i.p. injection of caerulein.</p></span></li></ul></div>\",\"PeriodicalId\":13733,\"journal\":{\"name\":\"International Journal of Biochemistry\",\"volume\":\"26 6\",\"pages\":\"Pages 805-811\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-711X(94)90110-4\",\"citationCount\":\"55\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0020711X94901104\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020711X94901104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Induction of heat shock protein and prevention of caerulein-induced pancreatitis by water-immersion stress in rats
Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. The effects of pre-treatment with water-immersion to caerulein-induced pancreatitis were investigated in this study.
1.
1. A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas.
2.
2. Intra-peritoneal injection of caerulein (40 μg/kg) induced acute pancreatitis in rats without pre-treatment with water-immersion. However, when the rats were pre-treated with water-immersion, acute pancreatitis was not developed and no change of serum amylase levels was observed by i.p. injection of caerulein.
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