PGBX(一种前列腺素聚合物)的结构特征通过与15-酮-前列腺素B二聚体的类比推断。

Physiological chemistry and physics Pub Date : 1981-01-01
B D Polis, E Polis, S F Kwong
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引用次数: 0

摘要

聚合前列腺素PGBX在体外对受损线粒体的氧化磷酸化有有益作用,在体内也表现出有趣的作用。通过与前列腺素单体的13C-NMR(核磁共振)谱的比较,部分阐明了其化学结构。本文报道了PGBX与两种由15-酮- pgb1衍生的前列腺素二聚体的后续比较,这两种二聚体提供了更完整的结构信息。合成了两种前列腺素二聚体,并通过13C-MNR和其他技术对其进行了分析,特别注意了二聚体中两个单体前列腺素亚基之间的连接位置。基于这些数据,提出了一些关于前列腺素单体亚基在聚合物PGBX中连接的可能位置的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural features of PGBX (a prostaglandin polymer) deduced by analogies with dimers derived from 15-keto-prostaglandin B.

The polymeric prostaglandin, PGBX, has a beneficial effect on oxidative phosphorylation of damaged mitochondria in vitro and has manifested interesting effects in vivo. Its chemical structure has been partially elucidated by comparison of its 13C-NMR (nuclear magnetic resonance) spectrum with the spectra of prostaglandin monomers. Reported here is subsequent comparison of PGBX with two prostaglandin dimers derived from 15-keto-PGB1, which provide more complete structural information. The two prostaglandin dimers were synthesized and analyzed by 13C-MNR and by other techniques, with particular attention to positions of linkages between the two monomeric prostaglandin subunits of the dimers. Based on these data, some proposals are presented regarding probable locations of linkages between prostaglandin monomeric subunits in the polymeric PGBX.

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