W. McIntyre Burnham, Gary A. King , Kenneth G. Lloyd
{"title":"点燃的大鼠前脑的焦外儿茶酚胺水平","authors":"W. McIntyre Burnham, Gary A. King , Kenneth G. Lloyd","doi":"10.1016/0364-7722(81)90042-4","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Levels of noradrenaline, dopamine and dopamine metabolites were measured in the striatum, limbic system and hypothalamus of amygdala-kindled and yoked control rats.</p></span></li><li><span>2.</span><span><p>2. Subjects were sacrificed three weeks after the kindled animals had displayed their fifth “Stage 5” generalized convulsion.</p></span></li><li><span>3.</span><span><p>3. No significant differences between kindled and control brains were found in any region except the hypothalamus. In the hypothalamus, noradrenaline and dopamine levels were significantly elevated in the kindled tissue. DOPAC was unchanged.</p></span></li><li><span>4.</span><span><p>4. The data suggest that amygdala kindling produces long lasting catecholaminergic changes in the hypothalamus, a major target for amygdaloid efferent fibers. They are in general agreement with the “noradrenaline hypothesis” of kindling.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 5","pages":"Pages 537-541"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90042-4","citationCount":"17","resultStr":"{\"title\":\"Extra-focal catecholamine levels in ‘kindled’ rat forebrains\",\"authors\":\"W. McIntyre Burnham, Gary A. King , Kenneth G. Lloyd\",\"doi\":\"10.1016/0364-7722(81)90042-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Levels of noradrenaline, dopamine and dopamine metabolites were measured in the striatum, limbic system and hypothalamus of amygdala-kindled and yoked control rats.</p></span></li><li><span>2.</span><span><p>2. Subjects were sacrificed three weeks after the kindled animals had displayed their fifth “Stage 5” generalized convulsion.</p></span></li><li><span>3.</span><span><p>3. No significant differences between kindled and control brains were found in any region except the hypothalamus. In the hypothalamus, noradrenaline and dopamine levels were significantly elevated in the kindled tissue. DOPAC was unchanged.</p></span></li><li><span>4.</span><span><p>4. The data suggest that amygdala kindling produces long lasting catecholaminergic changes in the hypothalamus, a major target for amygdaloid efferent fibers. They are in general agreement with the “noradrenaline hypothesis” of kindling.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":\"5 5\",\"pages\":\"Pages 537-541\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90042-4\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900424\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900424","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Extra-focal catecholamine levels in ‘kindled’ rat forebrains
1.
1. Levels of noradrenaline, dopamine and dopamine metabolites were measured in the striatum, limbic system and hypothalamus of amygdala-kindled and yoked control rats.
2.
2. Subjects were sacrificed three weeks after the kindled animals had displayed their fifth “Stage 5” generalized convulsion.
3.
3. No significant differences between kindled and control brains were found in any region except the hypothalamus. In the hypothalamus, noradrenaline and dopamine levels were significantly elevated in the kindled tissue. DOPAC was unchanged.
4.
4. The data suggest that amygdala kindling produces long lasting catecholaminergic changes in the hypothalamus, a major target for amygdaloid efferent fibers. They are in general agreement with the “noradrenaline hypothesis” of kindling.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
