{"title":"乳酸钠引起的恐慌:电生理相关","authors":"Verner Knott, Rajnish Chaudhry, Yvon D. Lapierre","doi":"10.1016/0364-7722(81)90036-9","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. This pilot study examined physiological concomitants of lactate-precipitated panic in six patients selected according to DSM-III criteria for panic disorder.</p></span></li><li><span>2.</span><span><p>2. Electrophysiological measures of central, autonomic and skeletal-muscular activities were monitored during a baseline period, i.v. administration of 5% D/W and of 0.5 M sodium lactate.</p></span></li><li><span>3.</span><span><p>3. Panic episodes were elicited in all patients following lactate administration. Marked increases in HR, EOG and EMG together with EEG alpha reduction, P<sub>2</sub>-N<sub>2</sub> amplitude reductions of the AEP and paradoxical increases in EEG delta activity indicate that experimentally induced panic states are characterised by physiological hyperarousal.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90036-9","citationCount":"25","resultStr":"{\"title\":\"Panic induced by sodium lactate: Electrophysiological correlates\",\"authors\":\"Verner Knott, Rajnish Chaudhry, Yvon D. Lapierre\",\"doi\":\"10.1016/0364-7722(81)90036-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. This pilot study examined physiological concomitants of lactate-precipitated panic in six patients selected according to DSM-III criteria for panic disorder.</p></span></li><li><span>2.</span><span><p>2. Electrophysiological measures of central, autonomic and skeletal-muscular activities were monitored during a baseline period, i.v. administration of 5% D/W and of 0.5 M sodium lactate.</p></span></li><li><span>3.</span><span><p>3. Panic episodes were elicited in all patients following lactate administration. Marked increases in HR, EOG and EMG together with EEG alpha reduction, P<sub>2</sub>-N<sub>2</sub> amplitude reductions of the AEP and paradoxical increases in EEG delta activity indicate that experimentally induced panic states are characterised by physiological hyperarousal.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90036-9\",\"citationCount\":\"25\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Panic induced by sodium lactate: Electrophysiological correlates
1.
1. This pilot study examined physiological concomitants of lactate-precipitated panic in six patients selected according to DSM-III criteria for panic disorder.
2.
2. Electrophysiological measures of central, autonomic and skeletal-muscular activities were monitored during a baseline period, i.v. administration of 5% D/W and of 0.5 M sodium lactate.
3.
3. Panic episodes were elicited in all patients following lactate administration. Marked increases in HR, EOG and EMG together with EEG alpha reduction, P2-N2 amplitude reductions of the AEP and paradoxical increases in EEG delta activity indicate that experimentally induced panic states are characterised by physiological hyperarousal.
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