Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman
{"title":"氟哌啶醇血浆水平的理论和实践重要性。与临床和计算机脑电图数据的相关性","authors":"Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman","doi":"10.1016/0364-7722(81)90033-3","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications.</p></span></li><li><span>2.</span><span><p>2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection.</p></span></li><li><span>3.</span><span><p>3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels.</p></span></li><li><span>4.</span><span><p>4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90033-3","citationCount":"17","resultStr":"{\"title\":\"Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data\",\"authors\":\"Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman\",\"doi\":\"10.1016/0364-7722(81)90033-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications.</p></span></li><li><span>2.</span><span><p>2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection.</p></span></li><li><span>3.</span><span><p>3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels.</p></span></li><li><span>4.</span><span><p>4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90033-3\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900333\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900333","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data
1.
1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications.
2.
2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection.
3.
3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels.
4.
4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time.
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