人血清因子诱导人骨髓巨脂肪细胞的研究。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-10-01

I A Svet-Moldavskaya, G J Svet-Moldavsky, S N Zinzar, J F Holland, C Vergara, Z Arlin, B Koziner, B D Clarkson

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引用次数: 0

摘要

下面的证据表明，正常的人血清中含有一种强效的不可透析因子，在人骨髓培养中诱导大量的巨脂肪细胞，无论是正常的还是慢性粒细胞白血病。含有20%加热(56℃)人血清的培养基在7-14天内在塑料瓶或培养皿底部诱导几乎完整的单层脂肪细胞。胎牛血清不表现出这种效果，并将培养转向成纤维细胞的增殖。我们正在研究脂肪细胞在造血中的功能以及人血清中脂肪细胞诱导因子的生化性质。

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Induction of giant fat cells in human bone marrow culture by human serum factor.

Evidence is presented below that normal human sera contain a potent non-dialyzable factor inducing abundant giant fat cells in human bone marrow culture, normal as well as CML. Media with 20% heated (56 degrees C) human serum induce during 7-14 days almost complete monolayer of fat cells on the bottom of the plastic flasks or dishes. Fetal bovine sera do not exhibit this effect and shift cultures to the proliferation of fibroblasts. We are studying the functions of fat cells in hemopoiesis as well as the biochemical nature of fat cell-inducing factor in human sera.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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