{"title":"血浆亮氨酸清除紊乱引起的内源性抑郁症中色氨酸可用性降低","authors":"Svend E. Møller, Lars Kirk","doi":"10.1016/0364-7722(81)90080-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Brain uptake of tryptophan is regulated in part by competition from other plasma amino acids, e.g. leucine.</p></span></li><li><span>2.</span><span><p>2. Following oral L-leucine loading, plasma leucine clearance was normal in 3 depressives but decreased in one depressive who subsequently reacted to L-tryptophan treatment.</p></span></li><li><span>3.</span><span><p>3. It is suggested that a disturbed leucine clearance causes dietary leucine to remain elevated in plasma and that this effect, in turn, reduces brain uptake of tryptophan, and serotonin synthesis.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 3","pages":"Pages 277-279"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90080-1","citationCount":"8","resultStr":"{\"title\":\"Decreased tryptophan availability in endogenous depression caused by disturbed plasma leucine clearance\",\"authors\":\"Svend E. Møller, Lars Kirk\",\"doi\":\"10.1016/0364-7722(81)90080-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Brain uptake of tryptophan is regulated in part by competition from other plasma amino acids, e.g. leucine.</p></span></li><li><span>2.</span><span><p>2. Following oral L-leucine loading, plasma leucine clearance was normal in 3 depressives but decreased in one depressive who subsequently reacted to L-tryptophan treatment.</p></span></li><li><span>3.</span><span><p>3. It is suggested that a disturbed leucine clearance causes dietary leucine to remain elevated in plasma and that this effect, in turn, reduces brain uptake of tryptophan, and serotonin synthesis.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":\"5 3\",\"pages\":\"Pages 277-279\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90080-1\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900801\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Decreased tryptophan availability in endogenous depression caused by disturbed plasma leucine clearance
1.
1. Brain uptake of tryptophan is regulated in part by competition from other plasma amino acids, e.g. leucine.
2.
2. Following oral L-leucine loading, plasma leucine clearance was normal in 3 depressives but decreased in one depressive who subsequently reacted to L-tryptophan treatment.
3.
3. It is suggested that a disturbed leucine clearance causes dietary leucine to remain elevated in plasma and that this effect, in turn, reduces brain uptake of tryptophan, and serotonin synthesis.
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