Pardeep Ahluwalia, Darshan S. Grewaal, Radhey L. Singhal
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Brain gabaergic and dopaminergic systems following lithium treatment and withdrawal
1.
1. Changes in dopaminergic and GABAergic systems were examined in several brain regions following short-term lithium administration and subsequent withdrawal.
2.
2. Lithium administration appears to cause a reduction in turnover of dopamine in most regions examined. In addition, there may be increased turnover of GABA in the midbrain, with decreased GABA outflow in other regions.
3.
3. Lithium withdrawal resulted in enhanced striatal dopamine turnover, together with a further decrease in dopamine content in other brain regions. With the exception of striatum, GABAergic parameters returned towards control.
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