相关3个品系小鼠乙酰胆碱转换与攻击行为

Alexander G. Karczmar, Gisela H. Kindel
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引用次数: 4

摘要

1.1. 本研究比较了3种自交系小鼠CF-1、c57b1 / 6by和Balb-c-By的脑乙酰胆碱(ACh)和胆碱水平及ACh脑代谢;这些参数在对照(聚集)小鼠中测量,并遵循两种模式,轻度足震和隔离,单独或联合应用。采用酶放射法测定脑乙酰胆碱和胆碱;采用两种计算方法评估乙酰胆碱周转率。与其他两株小鼠相比,聚合Balb-c-By小鼠的乙酰胆碱和胆碱水平较低。C57B1/6 By和CF-1小鼠的ACh水平无显著差异;CF-1小鼠的胆碱水平几乎是c57b1 / 6by小鼠的两倍。聚集CF-1小鼠的ACh周转率约为C57B1/6 By的2倍,比Balb-c-By小鼠高2倍以上。休克、分离或休克联合分离对3种毒株小鼠脑内乙酰胆碱和胆碱水平的影响不一致,而且经常没有影响。无论是单独使用还是联合使用,两种模式均显著降低了CF-1脑内乙酰胆碱的周转率;足震联合隔离无加性效应。在C57B1/6 By和Balb-c-By小鼠的情况下,单独或联合使用两种范式后,乙酰胆碱酯酶的周转率没有一致的变化;在某些情况下,乙酰胆碱周转率增加。在3个小鼠品系中,足震对攻击的诱导作用较弱;在3株菌株中,足震与分离相结合证明具有协同增效作用。无论是单独暴露于足震和隔离,还是联合暴露于足震和隔离,CF-1小鼠的攻击性都明显强于Balb-c-By和C57B1/6 By小鼠。强调两种范式对攻击行为的一致性促进效应以及足部冲击与孤立相结合对攻击行为的加性效应应与单独或单独应用两种范式对乙酰胆碱转换的不一致性效应进行对比;总之,这些数据并没有表明攻击性与大脑乙酰胆碱转换增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acetylcholine turnover and aggression in related three strains of mice

  • 1.

    1. This study compares brain levels of acetylcholine (ACh) and choline, and ACh brain turnover in 3 inbred strains of mice, CF-1, C57B1/6 By and Balb-c-By; these parameters were measured in control (aggregated) mice as well as following two paradigms, mild footshock and isolation, applied alone or in combination.

  • 2.

    2. Enzymic radioassay method was used to measure brain ACh and choline; ACh turnover was evaluated by two computation methods.

  • 3.

    3. Aggregated Balb-c-By mice exhibited low ACh and choline levels as compared to those of the mice of the two other strains. ACh levels of C57B1/6 By and CF-1 mice did not differ significantly; choline levels of CF-1 mice were almost twofold higher than those of C57B1/6 By mice.

  • 4.

    4. ACh turnover of aggregated CF-1 mice was about twice as high as that of C57B1/6 By and more than twice higher than that of Balb-c-By mice.

  • 5.

    5. The effects of shock, isolation, or shock combined with isolation on the brain levels of ACh and choline of mice of the 3 strains were inconsistent and, frequently absent.

  • 6.

    6. ACh turnover was significantly decreased in the brains of CF-1 by the two paradigms, whether employed alone or in combination; there was no additive effect when footshock was combined with isolation.

  • 7.

    7. ACh turnover did not change consistently after the two paradigms, employed alone or in combination, in the case of C57B1/6 By and Balb-c-By mice; in some cases, ACh turnover was increased.

  • 8.

    8. Footshock proved to be a mild inducer of aggression as compared to isolation in the 3 mice strains; footshock combined with isolation proved to synergize with respect to aggression in the 3 strains. Whether exposed to footshock and isolation alone or to the combination of these procedures, CF-1 mice were significantly more aggressive than Balb-c-By and C57B1/6 By mice.

  • 9.

    9. It is emphasized that consistent facilitatory effect of the two paradigms on aggression as well as additive effect on aggression resulting from combining footshock and isolation should be contrasted with the inconsistent effects of the two paradigms, applied alone or in isolation, on ACh turnover; altogether, the data did not indicate that aggression is related to increased brain ACh turnover.

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