(琥珀胆碱。人体除全身麻醉外的血流动力学研究[作者简介]。

Anesthesie, analgesie, reanimation Pub Date : 1981-01-01
M Guggiari, A Lienhart, Y Gallais, A Tauvent, P Viars
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引用次数: 0

摘要

研究了1 mg/kg苏沙莫铵对8例机械通气、血压正常的昏迷患者的血流动力学影响。避免药物干扰,包括阿托品。观察到心率和心输出量(CO)在第一分钟短暂但显著增加,分别为+ 27% (p < 0.02)和+ 29% (p < 0.025)。右耳穴、肺毛细血管楔和肺动脉压从第1分钟到第8分钟明显升高。无论全身动脉阻力从第一分钟的- 11% (p < 0.02)下降,平均动脉血压均无显著升高(+ 5%)。在整个研究过程中未发生心律失常。在本研究条件下,磺胺磺胺可诱导早期短暂性CO升高。心动过速和静脉回流增加均可解释CO升高。这种升高可能是由于短暂性腹部高压引起的,这可能是心力衰竭患者对磺胺磺胺耐受性差的因素之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Suxamethonium. Haemodynamic study in man excepting general anaesthesia (author's transl)].

Haemodynamic effects of suxamethonium IV 1 mg/kg were studied in eight comatose, mechanicaly ventilated, normotensive patients. Drug interference, including atropine was avoid. A transitory but significant increase in heart rate and cardiac output (CO) was observed, respectively + 27 p. cent (p less than 0.02) and + 29 p. cent (p less than 0.025) at the first minute. Right auricular, pulmonary capillary wedge, and pulmonary arterial pressures increased significantly from the first to the eighth minute. Mean arterial blood pressure unsignificantly increased (+ 5 p. cent) wether systemic arterial resistance decreased from - 11 p. cent (p less than 0.02) at the first minute. No arrhythmia occurred throughout the study. In the conditions of this study suxamethonium induces an early and transient increase in CO. Both tachycardia and increased venous return can explain the rise in CO. Such an increase could be due to the transient abdominal hyperpressure, and can be one of the factors which explain the poor tolerance of suxamethonium in patients with heart failure.

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