G Gachelin, B Dumas, J P Abastado, B Cami, J Papamatheakis, P Kourilsky
{"title":"小鼠主要I类移植抗原编码基因:一种镶嵌结构可能与抗原多态性有关。","authors":"G Gachelin, B Dumas, J P Abastado, B Cami, J Papamatheakis, P Kourilsky","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The recent isolation, by recombinant DNA techniques, of cloned probes for mouse and human class I major transplantation antigens has initiated the molecular analysis of the corresponding genes. Mouse genes belong to a relatively large multigene family, whose members share extensive structural homologies. Sequence analyses suggest that some genes could have a mosaic structure. This feature might help us to understand one of the distinctive traits of these antigens: their large antigenic polymorphism.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133C 1","pages":"3-20"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mouse genes coding for the major class I transplantation antigens: a mosaic structure might be related to the antigenic polymorphism.\",\"authors\":\"G Gachelin, B Dumas, J P Abastado, B Cami, J Papamatheakis, P Kourilsky\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The recent isolation, by recombinant DNA techniques, of cloned probes for mouse and human class I major transplantation antigens has initiated the molecular analysis of the corresponding genes. Mouse genes belong to a relatively large multigene family, whose members share extensive structural homologies. Sequence analyses suggest that some genes could have a mosaic structure. This feature might help us to understand one of the distinctive traits of these antigens: their large antigenic polymorphism.</p>\",\"PeriodicalId\":75508,\"journal\":{\"name\":\"Annales d'immunologie\",\"volume\":\"133C 1\",\"pages\":\"3-20\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales d'immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales d'immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mouse genes coding for the major class I transplantation antigens: a mosaic structure might be related to the antigenic polymorphism.
The recent isolation, by recombinant DNA techniques, of cloned probes for mouse and human class I major transplantation antigens has initiated the molecular analysis of the corresponding genes. Mouse genes belong to a relatively large multigene family, whose members share extensive structural homologies. Sequence analyses suggest that some genes could have a mosaic structure. This feature might help us to understand one of the distinctive traits of these antigens: their large antigenic polymorphism.
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