同种移植肾中肾素对速尿的反应。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-07-01

M Lebel, J G Lachance, J H Grose

{"title":"同种移植肾中肾素对速尿的反应。","authors":"M Lebel, J G Lachance, J H Grose","doi":"","DOIUrl":null,"url":null,"abstract":"Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"35 3","pages":"81-4"},"PeriodicalIF":0.0000,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Renin responsiveness to furosemide in the homotransplanted kidney.\",\"authors\":\"M Lebel, J G Lachance, J H Grose\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.\",\"PeriodicalId\":9217,\"journal\":{\"name\":\"Biomedicine / [publiee pour l'A.A.I.C.I.G.]\",\"volume\":\"35 3\",\"pages\":\"81-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedicine / [publiee pour l'A.A.I.C.I.G.]\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

对16例既往行双侧肾切除术的正常血压同型肾移植患者进行重复速尿刺激后的血浆肾素活性(PRA)进行测量。移植后即刻，PRA对呋塞米的反应百分比非常低(34%)，但随着时间的推移逐渐增加到一年后的水平(111%)，与年龄和性别匹配的对照组相比无统计学差异。PRA升高百分比与移植后周数有显著相关性(r = 0.48, P < 0.01)。这些数据表明，移植后肾小球旁细胞对速尿的反应是定量的时间依赖性的，这是评估此类患者肾素-血管紧张素系统时应考虑的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Renin responsiveness to furosemide in the homotransplanted kidney.

Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biomedicine / [publiee pour l'A.A.I.C.I.G.]

自引率

0.00%

发文量