IgA肾小球肾炎患者的循环免疫复合物。

J Nagy, G Füst, M Ambrus, C Trinn, M Paál, T Burger
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引用次数: 0

摘要

本文对44例IgA-肾小球肾炎(IgA GN)患者在病程中反复检测循环免疫复合物(IC),采用补体消耗法、clq溶解度法和peg沉淀法检测IC。直接和间接体征的联合评估(至少2个间接体征或任何直接体征的阳性)允许在72%的患者和63.3%的检查血清中确定循环IC的存在。IC的存在与临床活动无密切关系。另一方面,在16例类风湿因子(RF)阳性的患者中,肾活检材料显示广泛的血管病变。研究结果表明,循环IC,其中一些含有RF,在IgA GN的病理机制中发挥作用,并参与该疾病血管异常的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating immune complexes in patients with IgA glomerulonephritis.

Fourty-four patients with IgA-glomerulonephritis (IgA GN) were studied for circulating immune complexes (IC) repeatedly in the course of disease on the evidence of four different methods suited for the detection of IC, viz. complement consumption assay, Clq-solubility test and two tests based on PEG-precipitation, and of indirect signs pointing to the presence of IC. Joint assessment of the direct and indirect signs (positivity of a minimum of 2 indirect signs or any of the direct signs) permitted to ascertain the presence of circulating IC in 72 per cent of the patients and in 63.3 per cent of the examined sera. There was no close relationship between the presence of IC and the clinical activity. On the other hand, in 16 patients positive for the rheumatoid factor (RF) the renal biopsy material revealed extensive vascular lesions. The findings suggest that the circulating IC, some of which contain RF, play a part in the pathomechanism of IgA GN and are involved in the production of the vascular abnormalities in this disease.

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