{"title":"连续稀释倍他米松-17-戊酸对漂烫电位和化学稳定性的影响。","authors":"K S Ryatt, J A Cotterill, A Mehta","doi":"10.1111/j.1365-2710.1983.tb01044.x","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of serial dilution of betamethasone-17-valerate (Betnovate ointment) in Unguentum Merck was investigated using a single application blanching assay in 10 subjects and high performance liquid chromatography. There was no statistically significant difference between any of the diluted formulations with regard to blanching potential. Chemical stability was maintained following a 1:32 dilution for 2 months and 1:4 dilution for 5 months at least, after storage at room temperature.</p>","PeriodicalId":77862,"journal":{"name":"Journal of clinical and hospital pharmacy","volume":"8 2","pages":"143-5"},"PeriodicalIF":0.0000,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2710.1983.tb01044.x","citationCount":"11","resultStr":"{\"title\":\"The effect of serial dilution of betamethasone-17-valerate on blanching potential and chemical stability.\",\"authors\":\"K S Ryatt, J A Cotterill, A Mehta\",\"doi\":\"10.1111/j.1365-2710.1983.tb01044.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of serial dilution of betamethasone-17-valerate (Betnovate ointment) in Unguentum Merck was investigated using a single application blanching assay in 10 subjects and high performance liquid chromatography. There was no statistically significant difference between any of the diluted formulations with regard to blanching potential. Chemical stability was maintained following a 1:32 dilution for 2 months and 1:4 dilution for 5 months at least, after storage at room temperature.</p>\",\"PeriodicalId\":77862,\"journal\":{\"name\":\"Journal of clinical and hospital pharmacy\",\"volume\":\"8 2\",\"pages\":\"143-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1365-2710.1983.tb01044.x\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical and hospital pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/j.1365-2710.1983.tb01044.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical and hospital pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1365-2710.1983.tb01044.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of serial dilution of betamethasone-17-valerate on blanching potential and chemical stability.
The effect of serial dilution of betamethasone-17-valerate (Betnovate ointment) in Unguentum Merck was investigated using a single application blanching assay in 10 subjects and high performance liquid chromatography. There was no statistically significant difference between any of the diluted formulations with regard to blanching potential. Chemical stability was maintained following a 1:32 dilution for 2 months and 1:4 dilution for 5 months at least, after storage at room temperature.
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