{"title":"脱氧核糖核酸/抗脱氧核糖核酸复合物解离与抑制结合的比较。","authors":"R J Smeenk, L A Aarden, C J van Oss","doi":"10.3109/08820138309066867","DOIUrl":null,"url":null,"abstract":"<p><p>A study was made of the increases in ionic strength (mu) and in pH that would effect: a) the inhibition of association of anti-double stranded (ds) DNA and dsDNA, and b) the dissociation of anti-dsDNA from dsDNA, with respect to high avidity as well as to low avidity human anti-dsDNA antibodies, using Crithidia luciliae kinetoplasts as a source of dsDNA. The results obtained appear to indicate that the electrostatic component of the antigen-antibody bond does not become stronger with time (for times spans less than 1 hr).</p>","PeriodicalId":13417,"journal":{"name":"Immunological communications","volume":"12 2","pages":"177-88"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08820138309066867","citationCount":"27","resultStr":"{\"title\":\"Comparison between dissociation and inhibition of association of DNA/anti-DNA complexes.\",\"authors\":\"R J Smeenk, L A Aarden, C J van Oss\",\"doi\":\"10.3109/08820138309066867\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A study was made of the increases in ionic strength (mu) and in pH that would effect: a) the inhibition of association of anti-double stranded (ds) DNA and dsDNA, and b) the dissociation of anti-dsDNA from dsDNA, with respect to high avidity as well as to low avidity human anti-dsDNA antibodies, using Crithidia luciliae kinetoplasts as a source of dsDNA. The results obtained appear to indicate that the electrostatic component of the antigen-antibody bond does not become stronger with time (for times spans less than 1 hr).</p>\",\"PeriodicalId\":13417,\"journal\":{\"name\":\"Immunological communications\",\"volume\":\"12 2\",\"pages\":\"177-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/08820138309066867\",\"citationCount\":\"27\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunological communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/08820138309066867\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/08820138309066867","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison between dissociation and inhibition of association of DNA/anti-DNA complexes.
A study was made of the increases in ionic strength (mu) and in pH that would effect: a) the inhibition of association of anti-double stranded (ds) DNA and dsDNA, and b) the dissociation of anti-dsDNA from dsDNA, with respect to high avidity as well as to low avidity human anti-dsDNA antibodies, using Crithidia luciliae kinetoplasts as a source of dsDNA. The results obtained appear to indicate that the electrostatic component of the antigen-antibody bond does not become stronger with time (for times spans less than 1 hr).
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