{"title":"氨基酸前体对脑内儿茶酚胺合成的影响","authors":"David J. Edwards, Marguerite Rizk","doi":"10.1016/0364-7722(81)90048-5","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.</p></span></li><li><span>2.</span><span><p>2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.</p></span></li><li><span>3.</span><span><p>3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.</p></span></li><li><span>4.</span><span><p>4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.</p></span></li><li><span>5.</span><span><p>5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 5","pages":"Pages 569-572"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90048-5","citationCount":"17","resultStr":"{\"title\":\"Effects of amino acid precursors on catecholamine synthesis in the brain\",\"authors\":\"David J. Edwards, Marguerite Rizk\",\"doi\":\"10.1016/0364-7722(81)90048-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.</p></span></li><li><span>2.</span><span><p>2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.</p></span></li><li><span>3.</span><span><p>3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.</p></span></li><li><span>4.</span><span><p>4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.</p></span></li><li><span>5.</span><span><p>5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":\"5 5\",\"pages\":\"Pages 569-572\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90048-5\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900485\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900485","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of amino acid precursors on catecholamine synthesis in the brain
1.
1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.
2.
2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.
3.
3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.
4.
4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.
5.
5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
