{"title":"氨基酸前体对脑内儿茶酚胺合成的影响","authors":"David J. Edwards, Marguerite Rizk","doi":"10.1016/0364-7722(81)90048-5","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.</p></span></li><li><span>2.</span><span><p>2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.</p></span></li><li><span>3.</span><span><p>3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.</p></span></li><li><span>4.</span><span><p>4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.</p></span></li><li><span>5.</span><span><p>5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90048-5","citationCount":"17","resultStr":"{\"title\":\"Effects of amino acid precursors on catecholamine synthesis in the brain\",\"authors\":\"David J. Edwards, Marguerite Rizk\",\"doi\":\"10.1016/0364-7722(81)90048-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.</p></span></li><li><span>2.</span><span><p>2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.</p></span></li><li><span>3.</span><span><p>3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.</p></span></li><li><span>4.</span><span><p>4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.</p></span></li><li><span>5.</span><span><p>5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90048-5\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900485\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900485","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of amino acid precursors on catecholamine synthesis in the brain
1.
1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.
2.
2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.
3.
3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.
4.
4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.
5.
5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.
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