Tamm-Horsfall蛋白与红细胞鬼免疫交叉反应。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

L Hartmann, J Delaunay, M P Ollier-Hartmann, A Bringuier, G Richet

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引用次数: 0

摘要

兔培养抗人Tamm-Horsfall蛋白(THP)和红细胞鬼影的血清。纯化后用血清白蛋白排出。使用放射免疫测定法，抗THP血清可以在红细胞鬼影中检测到每毫克膜蛋白41纳克的反应物质。Ouchterlony双扩散技术显示了类似的交叉反应，相反，THP和抗血清对红细胞鬼影有交叉反应。这些数据支持了红细胞膜含有一种与THP有关的化合物的观点。

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Tamm-Horsfall protein and erythrocyte ghosts immunologically cross-react.

Antisera were raised in the rabbit against human Tamm-Horsfall protein (THP) and erythrocyte ghosts. They were purified and exhausted with serumalbumin. Using a radioimmunoassay, antisera against THP allowed to detect in erythrocyte ghosts 41 ng of a reaction material per mg membrane protein. Ouchterlony double diffusion technique showed a similar corss-reaction and, conversely, a cross-reaction between THP and antisera to erythrocyte ghosts. These data support the view that red cell membrane contains a compound related to THP.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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